Mir146^tm1.1Jrnn
Targeted Allele Detail

Summary

• Symbol: Mir146^tm1.1Jrnn
• Name: microRNA 146; targeted mutation 1.1, Joel R Neilson
• MGI ID: MGI:6279766
• Synonyms: Mir146^3'F, Mir146^3'Flip
• Gene: Mir146 Location: Chr11:43265224-43265288 bp, - strand Genetic Position: Chr11, 25.68 cM
• Alliance: Mir146^tm1.1Jrnn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:270870
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutation: Nucleotide substitutions
• Mutation details:

  Sequences in both the 5' and 3' half of the gene were swapped and reversed (not complemented), changing UCCAUGGG in the encoded pre-Mir to AAGUGUCC and CCUGUGAA to GGGUACCU. Cre-mediated recombination removed the floxed neomycin selection cassette. (J:270870)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mir146 Mutation: 14 strains or lines available

References

• Original: J:270870 Bertolet G, et al., MiR-146a wild-type 3' sequence identity is dispensable for proper innate immune function in vivo. Life Sci Alliance. 2019 Feb;2(1)
• All: 1 reference(s)