Kdm6a^em2Masn
Endonuclease-mediated Allele Detail

Summary

• Symbol: Kdm6a^em2Masn
• Name: lysine (K)-specific demethylase 6A; endonuclease-mediated mutation 2, Masahide Asano
• MGI ID: MGI:6277165
• Synonyms: emdelta4, Utx^-
• Gene: Kdm6a Location: ChrX:18028814-18146175 bp, + strand Genetic Position: ChrX, 13.45 cM
• Alliance: Kdm6a^em2Masn page

Mutation origin

• Strain of Origin: (C57BL/6 x DBA/2)F1

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology generated a 4 bp deletion (ttgg) resulting in a frame-shift mutation that causes a C-terminal truncated nonfunctional protein. (J:247259)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kdm6a Mutation: 38 strains or lines available

References

• Original: J:247259 Naruse C, et al., New insights into the role of Jmjd3 and Utx in axial skeletal formation in mice. FASEB J. 2017 Jun;31(6):2252-2266
• All: 1 reference(s)