Tcf7^em1Hhx
Endonuclease-mediated Allele Detail

Summary

• Symbol: Tcf7^em1Hhx
• Name: transcription factor 7, T cell specific; endonuclease-mediated mutation 1, Hai-Hui Xue
• MGI ID: MGI:6277162
• Synonyms: Tcf1^deltaHMG
• Gene: Tcf7 Location: Chr11:52143198-52174158 bp, - strand Genetic Position: Chr11, 31.86 cM
• Alliance: Tcf7^em1Hhx page

Mutation origin

• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Endonuclease-mediated (Not Applicable)
• Mutation: Nucleotide substitutions
• Mutation details: CRISPR/cas9 mediated recombination inserted a stop codon on exon 8 after the codon encoding Val³⁰⁴. This mutation truncates the high mobility group (HMG) domain at the C terminus interfering with the intrinsic histone deacetylase (HDAC) activity. (J:247679)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tcf7 Mutation: 29 strains or lines available

References

• Original: J:247679 Xu Z, et al., Cutting Edge: beta-Catenin-Interacting Tcf1 Isoforms Are Essential for Thymocyte Survival but Dispensable for Thymic Maturation Transitions. J Immunol. 2017 May 01;198(9):3404-3409
• All: 3 reference(s)