Gab1^tm6.1Wbm
Targeted Allele Detail

Summary

• Symbol: Gab1^tm6.1Wbm
• Name: growth factor receptor bound protein 2-associated protein 1; targeted mutation 6.1, Walter Birchmeier
• MGI ID: MGI:6277118
• Synonyms: Gab1^loxp
• Gene: Gab1 Location: Chr8:81491063-81607148 bp, - strand Genetic Position: Chr8, 38.47 cM, cytoband C3
• Alliance: Gab1^tm6.1Wbm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:269458
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exon 4 was flanked by loxP sites and a FRT-flanked neomycin cassette was inserted downstream of the floxed exon. Flp-mediated recombination removed the neomycin cassette leaving exon 4 floxed. (J:269458)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gab1 Mutation: 79 strains or lines available

References

• Original: J:269458 Akilli Ozturk O, et al., Gab1 and Mapk Signaling Are Essential in the Hair Cycle and Hair Follicle Stem Cell Quiescence. Cell Rep. 2015 Oct 20;13(3):561-572
• All: 1 reference(s)