Tg(LCR-HBA2,LCR-HBB*E26K)53Hhb
Transgene Detail

Summary

• Symbol: Tg(LCR-HBA2,LCR-HBB*E26K)53Hhb
• Name: transgene insertion 53, Henny Billett
• MGI ID: MGI:6277105
• Synonyms: HbE
• Transgene: Tg(LCR-HBA2,LCR-HBB*E26K)53Hhb Location: unknown
• Alliance: Tg(LCR-HBA2,LCR-HBB*E26K)53Hhb page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: The transgenic insert contains the human alpha globin 2 (HBA2) gene under the control of the locus control region (LCR) of the human beta globin gene and a second transgenic insert containing a mutant human beta globin (HBB) gene with the E26K point mutation (position 26 glutamic acid to lysine). The E26K point mutation results in a hemoglobin variant called hemoglobin E. Hemoglobin E is most commonly found in people from Southeast Asia. (J:134035)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:134035 Chen Q, et al., Generation of transgenic mice expressing human hemoglobin E. Blood Cells Mol Dis. 2004 Nov-Dec;33(3):303-7
• All: 2 reference(s)