Epas1^em1Rkbk
Endonuclease-mediated Allele Detail

Summary

• Symbol: Epas1^em1Rkbk
• Name: endothelial PAS domain protein 1; endonuclease-mediated mutation 1, Richard K Bruick
• MGI ID: MGI:6276630
• Synonyms: Epas1^S305M
• Gene: Epas1 Location: Chr17:87061292-87140838 bp, + strand Genetic Position: Chr17, 56.9 cM
• Alliance: Epas1^em1Rkbk page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Nucleotide substitutions
• Mutation details: Zinc finger endonuclease-mediated mutation introduced nucleotide substitutions in exon 8 that result in the amino acid substitution of methionine for serine at position 305 (S305M) and a silent mutation. (J:268894)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Epas1 Mutation: 66 strains or lines available

References

• Original: J:268894 Feng Z, et al., Modulation of HIF-2alpha PAS-B domain contributes to physiological responses. Proc Natl Acad Sci U S A. 2018 Dec 26;115(52):13240-13245
• All: 1 reference(s)