Tg(LCR-HBG2*/HBG1)203Hhb
Transgene Detail

Summary

• Symbol: Tg(LCR-HBG2*/HBG1)203Hhb
• Name: transgene insertion 203, Henny Billett
• MGI ID: MGI:6276606
• Synonyms: gammaM
• Transgene: Tg(LCR-HBG2*/HBG1)203Hhb Location: unknown
• Alliance: Tg(LCR-HBG2*/HBG1)203Hhb page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: The transgene contains a PCR-generated 4.3kb fragment of the human HBB gene (912-5200) containing HS3 and HS4 of the human beta-globin locus control regions (LCR) inserted into a 12.4-kb fragment of the human HBB gene (32837-45203) including the mutant human HBG2 gene with a T at position -158 relative to the cap site, the HBG1 gene and the 3' enhancer. Founder line G203 was established and found to have multiple copies of the transgene. (J:66961)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:66961 Fabry ME, et al., Second generation knockout sickle mice: the effect of HbF. Blood. 2001 Jan 15;97(2):410-8
• All: 2 reference(s)