Tlr8^em1Yjg
Endonuclease-mediated Allele Detail

Summary

• Symbol: Tlr8^em1Yjg
• Name: toll-like receptor 8; endonuclease-mediated mutation 1, Yong-Jing Gao
• MGI ID: MGI:6276305
• Gene: Tlr8 Location: ChrX:166025692-166047325 bp, - strand Genetic Position: ChrX, 78.29 cM, cytoband F5
• Alliance: Tlr8^em1Yjg page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: TALEN-targeting deleted 12 bp in exon 2. Immunostaining confirmed the absence of protein in the dorsal root ganglia. (J:269886)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tlr8 Mutation: 9 strains or lines available

References

• Original: J:269886 Zhang ZJ, et al., TLR8 and its endogenous ligand miR-21 contribute to neuropathic pain in murine DRG. J Exp Med. 2018 Dec 3;215(12):3019-3037
• All: 1 reference(s)