Tg(Thy1-YFP)W3Jrs
Transgene Detail

Summary

• Symbol: Tg(Thy1-YFP)W3Jrs
• Name: transgene insertion W3, Joshua R Sanes
• MGI ID: MGI:6276103
• Synonyms: TYW3
• Transgene: Tg(Thy1-YFP)W3Jrs Location: Chr1:31784833-32204143 bp Genetic Position: Chr1, Syntenic
• Alliance: Tg(Thy1-YFP)W3Jrs page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Reporter)
• Mutations: Insertion, Intergenic deletion
• Mutation details: Mouse Thy1 regulatory elements drive expression of YFP. The transgene was intended to express WGA plus LacZ following excision of YFP by Cre, but neither WGA nor LacZ were expressed at detectable levels. In the TYW3 line, transgene is present in 5 tandem copies and insertion resulted in a 420 kb deletion 7 kb upstream of Khdrbs2. In this line, some RGCs are labeled brightly and others dimly, and more RGCs are labeled in the ventral portion of the retina than in the dorsal side. (J:157687, J:271391)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:157687 Kim IJ, et al., Laminar restriction of retinal ganglion cell dendrites and axons: subtype-specific developmental patterns revealed with transgenic markers. J Neurosci. 2010 Jan 27;30(4):1452-62
• All: 12 reference(s)