Pitx3^miak
Spontaneous Allele Detail

Summary

• Symbol: Pitx3^miak
• Name: paired-like homeodomain transcription factor 3; microphthalmia and aphakia
• MGI ID: MGI:6276099
• Gene: Pitx3 Location: Chr19:46124124-46136765 bp, - strand Genetic Position: Chr19, 38.75 cM
• Alliance: Pitx3^miak page

Mutation origin

• Strain of Origin: KOR1/Stm

Mutation description

• Allele Type: Spontaneous (Not Specified)
• Mutation: Single point mutation
• Mutation details: A spontaneous mutation produced a C-to-A point mutation that results in a premature termination codon instead of tyrosine at position 148 (p.Y148*). (J:269956)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pitx3 Mutation: 22 strains or lines available

References

• Original: J:269956 Wada K, et al., Expression of truncated PITX3 in the developing lens leads to microphthalmia and aphakia in mice. PLoS One. 2014;9(10):e111432
• All: 1 reference(s)