Tg(SOD1*D90A)134Mrkl
Transgene Detail

Summary

• Symbol: Tg(SOD1*D90A)134Mrkl
• Name: transgene insertion 134, Stefan L Marklund
• MGI ID: MGI:6276054
• Transgene: Tg(SOD1*D90A)134Mrkl Location: unknown
• Alliance: Tg(SOD1*D90A)134Mrkl page

Transgene origin

• Strain of Origin: C57BL/6 x CBA

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(SOD1*D90A)134Mrkl expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  SOD1 (6647)

  Sod1	(MGI:98351)

  mutated human gene

• Mutation details: The transgene contains the complete genomic sequence of the human superoxide dismutase 1, with a mutation in exon 4 changing codon 90 from aspartate to alanine (p.D90A). This mutation is the most common mutation found in amyotrophic lateral sclerosis (ALS) patients. Founders 134 and 154 had the highest transgene copy number and were selected for further study. (J:269950)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:269950 Jonsson PA, et al., Motor neuron disease in mice expressing the wild type-like D90A mutant superoxide dismutase-1. J Neuropathol Exp Neurol. 2006 Dec;65(12):1126-36
• All: 1 reference(s)