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Transgene Detail
Symbol: Tg(Myh6-Camk2d_ic)LJhb
Name: transgene insertion L, Joan Heller Brown
MGI ID: MGI:6276041
Synonyms: TGL
Transgene: Tg(Myh6-Camk2d_ic)LJhb  Location: unknown  
Alliance: Tg(Myh6-Camk2d_ic)LJhb page
Strain of Origin:  Not Specified
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
Tg(Myh6-Camk2d_ic)LJhb expresses 1 gene
Mutation detailsA hemagglutinin (HA)-tagged rat cDNA for the cytoplasmic variant of Camk2d is under the control of the 5.5-kb murine alpha-MHC promoter. Immunocytochemical staining confirmed that the expressed transgene is expressed only in the heart and is confined in the cytoplasm of cardiomyocytes. Three lines (TGL, TGM, and TGH) were generated. This TGL line carries 3 copies of the transgene and is the low copy number line. Protein levels are increased 12-fold over wild-type levels but the amount of activated Camk2d is only increased 1.7-fold in hearts. (J:130644)
View phenotypes and curated references for all genotypes (concatenated display).
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Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Original:  J:130644 Zhang T, et al., The deltaC isoform of CaMKII is activated in cardiac hypertrophy and induces dilated cardiomyopathy and heart failure. Circ Res. 2003 May 2;92(8):912-9
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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MGI 6.22
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