About   Help   FAQ
Tg(Myh6-Camk2d_ic)LJhb
Transgene Detail
Summary
Symbol: Tg(Myh6-Camk2d_ic)LJhb
Name: transgene insertion L, Joan Heller Brown
MGI ID: MGI:6276041
Synonyms: TGL
Transgene: Tg(Myh6-Camk2d_ic)LJhb  Location: unknown  
Alliance: Tg(Myh6-Camk2d_ic)LJhb page
Transgene
origin
Strain of Origin:  Not Specified
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Myh6-Camk2d_ic)LJhb expresses 1 gene
 
Mutation detailsA hemagglutinin (HA)-tagged rat cDNA for the cytoplasmic variant of Camk2d is under the control of the 5.5-kb murine alpha-MHC promoter. Immunocytochemical staining confirmed that the expressed transgene is expressed only in the heart and is confined in the cytoplasm of cardiomyocytes. Three lines (TGL, TGM, and TGH) were generated. This TGL line carries 3 copies of the transgene and is the low copy number line. Protein levels are increased 12-fold over wild-type levels but the amount of activated Camk2d is only increased 1.7-fold in hearts. (J:130644)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Loading...
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:130644 Zhang T, et al., The deltaC isoform of CaMKII is activated in cardiac hypertrophy and induces dilated cardiomyopathy and heart failure. Circ Res. 2003 May 2;92(8):912-9
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Copyright, and Privacy Statement
Send questions and comments to User Support.
last database update
01/31/2023
MGI 6.22
The Jackson Laboratory