Scn4b^em1Jmn
Endonuclease-mediated Allele Detail

Summary

• Symbol: Scn4b^em1Jmn
• Name: sodium channel, type IV, beta; endonuclease-mediated mutation 1, Jeanne Nerbonne
• MGI ID: MGI:6276033
• Gene: Scn4b Location: Chr9:45049922-45065453 bp, + strand Genetic Position: Chr9, 24.84 cM
• Alliance: Scn4b^em1Jmn page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A 10bp deletion was generated, resulting in a frameshift and introduces a stop codon at residue 137. The endoced protein is undetectable in mutant cerebellum, as shown by western blot. (J:250885)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Scn4b Mutation: 19 strains or lines available

References

• Original: J:250885 Ransdell JL, et al., Loss of Navbeta4-Mediated Regulation of Sodium Currents in Adult Purkinje Neurons Disrupts Firing and Impairs Motor Coordination and Balance. Cell Rep. 2017 Apr 18;19(3):532-544
• All: 1 reference(s)