Pax5^em2Cgmn
Endonuclease-mediated Allele Detail

Summary

• Symbol: Pax5^em2Cgmn
• Name: paired box 5; endonuclease-mediated mutation 2, Charles G Mullighan
• MGI ID: MGI:6276029
• Synonyms: Pax5^G183S, Pax5^p.Gly183Ser
• Gene: Pax5 Location: Chr4:44524757-44710487 bp, - strand Genetic Position: Chr4, 23.55 cM
• Alliance: Pax5^em2Cgmn page

Mutation origin

• Strain of Origin: C57BL/6NJ

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Nucleotide substitutions
• CRISPR-targeting induced the amino acid substitution of serine for glycine at position 183. (J:270049)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pax5 Mutation: 40 strains or lines available

References

• Original: J:270049 Gu Z, et al., PAX5-driven subtypes of B-progenitor acute lymphoblastic leukemia. Nat Genet. 2019 Feb;51(2):296-307
• All: 1 reference(s)