Crk^tm1.1Imo
Targeted Allele Detail

Summary

• Symbol: Crk^tm1.1Imo
• Name: v-crk avian sarcoma virus CT10 oncogene homolog; targeted mutation 1.1, Akira Imamoto
• MGI ID: MGI:6275121
• Synonyms: Crk^f
• Gene: Crk Location: Chr11:75570085-75597734 bp, + strand Genetic Position: Chr11, 45.92 cM, cytoband A-D
• Alliance: Crk^tm1.1Imo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:283745
• Parent Cell Line: PRX-129S6 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: The targeting vector contains an FRT site flanked PGKneo selection cassette with a downstream loxP site. This selection cassette was inserted downstream of exon 1 of the targeted gene, and another loxP site was inserted upstream of exon 1. FLP-mediated recombination removed the FRT-flanked neo cassette leaving exon 1 floxed. (J:283745)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Crk Mutation: 19 strains or lines available

References

• Original: J:283745 Imamoto A, et al., Essential role of the Crk family-dosage in DiGeorge-like anomaly and metabolic homeostasis. Life Sci Alliance. 2020 Feb;3(2)
• All: 1 reference(s)