Mir22hg^tm1.1Boet
Targeted Allele Detail

Summary

• Symbol: Mir22hg^tm1.1Boet
• Name: Mir22 host gene (non-protein coding); targeted mutation 1.1, Thomas Boettger
• MGI ID: MGI:6274716
• Synonyms: miR-22^d
• Gene: Mir22hg Location: Chr11:75352365-75357502 bp, + strand Genetic Position: Chr11, 45.91 cM
• Alliance: Mir22hg^tm1.1Boet page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:266382
• Parent Cell Line: MPI-II (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The estrogen receptor element in the first coding exon was replaced with a loxP site. Cre-mediated recombination removed the selection cassette. (J:266382)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mir22hg Mutation: 6 strains or lines available

References

• Original: J:266382 Schweisgut J, et al., Sex-specific, reciprocal regulation of ERalpha and miR-22 controls muscle lipid metabolism in male mice. EMBO J. 2017 May 2;36(9):1199-1214
• All: 1 reference(s)