Tab1^tm1.1Mhmr
Targeted Allele Detail

Summary

• Symbol: Tab1^tm1.1Mhmr
• Name: TGF-beta activated kinase 1/MAP3K7 binding protein 1; targeted mutation 1.1, Michael Marber
• MGI ID: MGI:6274707
• Synonyms: TAB1 (V390A, Y392A, V408G, and M409A)
• Gene: Tab1 Location: Chr15:80017333-80045908 bp, + strand Genetic Position: Chr15, 37.85 cM, cytoband E2
• Alliance: Tab1^tm1.1Mhmr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:267188
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Constitutively active)
• Mutation: Nucleotide substitutions
• Mutation details: Exon 10 was replaced with a floxed neomycin resistance cassette and a modified exon 10 with V390A, Y392A, V408G, and M409A mutations, which are predicted to prevent binding onto Mapk14. Cre-mediated recombination removed the selection cassette, allowing for expression of the constituitively active allele. (J:267188)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tab1 Mutation: 93 strains or lines available

References

• Original: J:267188 De Nicola GF, et al., The TAB1-p38alpha complex aggravates myocardial injury and can be targeted by small molecules. JCI Insight. 2018 Aug 23;3(16)
• All: 1 reference(s)