Nelfb^tm1.1Ehs
Targeted Allele Detail

Summary

• Symbol: Nelfb^tm1.1Ehs
• Name: negative elongation factor complex member B; targeted mutation 1.1, National Institute of Environmental Health Science
• MGI ID: MGI:6274273
• Synonyms: NELF-B f, Nelfb^tm2Ehs, NELF^FL
• Gene: Nelfb Location: Chr2:25089724-25101501 bp, - strand Genetic Position: Chr2, 17.06 cM
• Alliance: Nelfb^tm1.1Ehs page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:268957
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: The targeting construct contains a loxP site upstream of exon 1 and a loxP-flanked neomycin selection cassette downstream of exon 4. Cre-mediated recombination removed the floxed neo cassette. (J:268957)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Nelfb Mutation: 22 strains or lines available

References

• Original: J:200982 Gupte R, et al., Glucocorticoid receptor represses proinflammatory genes at distinct steps of the transcription cycle. Proc Natl Acad Sci U S A. 2013 Sep 3;110(36):14616-21
• All: 7 reference(s)