Mir16-1^m1
Spontaneous Allele Detail

Summary

• Symbol: Mir16-1^m1
• Name: microRNA 16-1; mutation 1
• MGI ID: MGI:6273332
• Gene: Mir16-1 Location: Chr14:61869329-61869421 bp, - strand Genetic Position: Chr14, 33.16 cM
• Alliance: Mir16-1^m1 page

Mutation origin

• Strain of Origin: NZB/BlNJ

Mutation description

• Allele Type: Spontaneous (Hypomorph)
• Mutation: Single point mutation
• Mutation details: A point mutation in the 3' DNA adjacent to pre-mir-16-1 region in NZB. A T-to-A mutation at base 61,631,880 (GRCm38) on the sense strand of chr 14 in the NZB/BlNJ strain is not present in DBA/2J, C57BL/6J, SJL/J, NZW, BALB/c, and NOD/SCID. Levels of miR-16 were decreased in NZB lymphoid tissue. (J:124364)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mir16-1 Mutation: 4 strains or lines available

References

• Original: J:124364 Raveche ES, et al., Abnormal microRNA-16 locus with synteny to human 13q14 linked to CLL in NZB mice. Blood. 2007 Jun 15;109(12):5079-86
• All: 4 reference(s)