Hmox1^tm1Mym
Targeted Allele Detail

Summary

• Symbol: Hmox1^tm1Mym
• Name: heme oxygenase 1; targeted mutation 1, Masayuki Yamamoto
• MGI ID: MGI:6273190
• Synonyms: Hmox1^fl
• Gene: Hmox1 Location: Chr8:75820249-75827217 bp, + strand Genetic Position: Chr8, 35.59 cM, cytoband C1
• Alliance: Hmox1^tm1Mym page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:262877
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: Exon 3 to 5 was flanked by loxP sites, followed by a fluorescent dsRED2 gene cassette inserted in the 3'UTR. The dsRED2 is expressed after cre-mediated recombination of loxP sites. (J:262877, J:268766)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Hmox1 Mutation: 33 strains or lines available

References

• Original: J:262877 Mamiya T, et al., Hepatocyte-specific deletion of heme oxygenase-1 disrupts redox homeostasis in basal and oxidative environments. Tohoku J Exp Med. 2008 Dec;216(4):331-9
• All: 20 reference(s)