Mre11a^tm3.1Dof
Targeted Allele Detail

Summary

• Symbol: Mre11a^tm3.1Dof
• Name: MRE11A homolog A, double strand break repair nuclease; targeted mutation 3.1, David O Ferguson
• MGI ID: MGI:6272743
• Synonyms: Mre11^ASM
• Gene: Mre11a Location: Chr9:14695971-14748421 bp, + strand Genetic Position: Chr9, 4.33 cM
• Alliance: Mre11a^tm3.1Dof page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:268252
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Modified isoform(s))
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 10 along with 181 intronic bases upstream and 234 bases downstream were replaced with a loxP-flanked neomycin resistance cassette. The neo was removed via cre-mediated recombination. RT-PCR and sequencing confirmed the expression of the shorter 9-11 splice variant RNA. (J:268252)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mre11a Mutation: 48 strains or lines available

References

• Original: J:268252 Hartlerode AJ, et al., Reversible mislocalization of a disease-associated MRE11 splice variant product. Sci Rep. 2018 Jul 4;8(1):10121
• All: 1 reference(s)