Calca^tm1Mnaka
Targeted Allele Detail

Summary

• Symbol: Calca^tm1Mnaka
• Name: calcitonin/calcitonin-related polypeptide, alpha; targeted mutation 1, Misa Nakamura
• MGI ID: MGI:6272741
• Gene: Calca Location: Chr7:114230713-114235592 bp, - strand Genetic Position: Chr7, 59.99 cM
• Alliance: Calca^tm1Mnaka page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:268579
• Parent Cell Line: RENKA (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced exon 4. RT-PCR on thyroid glands confirmed absence of calcitonin (CT) mRNA, but presence of calcitonin gene-related peptide alpha (alphaCGRP) mRNA. (J:268579)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Calca Mutation: 25 strains or lines available

References

• Original: J:268579 Nakamura M, et al., Endogenous calcitonin regulates lipid and glucose metabolism in diet-induced obesity mice. Sci Rep. 2018 Nov 19;8(1):17001
• All: 1 reference(s)