Rtn4^tm1.1Bzh
Targeted Allele Detail

Summary

• Symbol: Rtn4^tm1.1Bzh
• Name: reticulon 4; targeted mutation 1.1, Binhai Zheng
• MGI ID: MGI:6272679
• Synonyms: Nogo^f
• Gene: Rtn4 Location: Chr11:29642947-29694331 bp, + strand Genetic Position: Chr11, 16.79 cM
• Alliance: Rtn4^tm1.1Bzh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:268491
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The first two exons common to all three major isoforms (A,B,C) were flanked by loxP sites and a neomycin selection cassette with a loxP at the N-terminus was inserted upstream of the floxed exons. Cre-mediated recombination excised the neomycin cassette generating a conditional allele. Removal of the two floxed exons eliminates the expression of the growth inhibitory Nogo-66 amino acid loop shared by all three isoforms and is predicted to result in a null for the C isoform and severe hypomorph for the A and B isoforms. (J:268491)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rtn4 Mutation: 130 strains or lines available

References

• Original: J:268491 Meves JM, et al., Oligodendrocytic but not neuronal Nogo restricts corticospinal axon sprouting after CNS injury. Exp Neurol. 2018 Nov;309:32-43
• All: 2 reference(s)