Fgf12^em1Yuna
Endonuclease-mediated Allele Detail

Summary

• Symbol: Fgf12^em1Yuna
• Name: fibroblast growth factor 12; endonuclease-mediated mutation 1, Yukiko Nakamura
• MGI ID: MGI:6272678
• Gene: Fgf12 Location: Chr16:27978850-28571820 bp, - strand Genetic Position: Chr16, 19.38 cM, cytoband B1-B3
• Alliance: Fgf12^em1Yuna page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology generated a one base-pair deletion in exon 2. Western blotting confirmed absence of protein in inner ear tissue. (J:268487)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fgf12 Mutation: 18 strains or lines available

References

• Original: J:268487 Hanada Y, et al., Fibroblast growth factor 12 is expressed in spiral and vestibular ganglia and necessary for auditory and equilibrium function. Sci Rep. 2018 Jul 31;8(1):11491
• All: 1 reference(s)