Ripk1tm1.1Mkel
Targeted Allele Detail
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Symbol: |
Ripk1tm1.1Mkel |
Name: |
receptor (TNFRSF)-interacting serine-threonine kinase 1; targeted mutation 1.1, Michelle Kelliher |
MGI ID: |
MGI:6272324 |
Synonyms: |
Ripk1D138N |
Gene: |
Ripk1 Location: Chr13:34186346-34221130 bp, + strand Genetic Position: Chr13, 14.01 cM
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Alliance: |
Ripk1tm1.1Mkel page
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Germline Transmission: |
Earliest citation of germline transmission:
J:241205
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Parent Cell Line: |
Bruce 4 (ES Cell)
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Strain of Origin: |
B6.Cg-Thy1a
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Allele Type: |
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Targeted (Not Applicable) |
Mutation: |
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Single point mutation
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Mutation details: A floxed neo cassette was inserted into intron 3 and a mutation was introduced in exon 4 creating an aspartate to aspargine substitution at position 138 (p.D138N). Cre mediated recombination removed the neo cassette. This mutation alters kinase activity of the protein.
(J:241205)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Ripk1 Mutation: |
31 strains or lines available
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Original: |
J:241205 Polykratis A, et al., Cutting edge: RIPK1 Kinase inactive mice are viable and protected from TNF-induced necroptosis in vivo. J Immunol. 2014 Aug 15;193(4):1539-43 |
All: |
23 reference(s) |
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