Ikzf2^em1Ronh
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ikzf2^em1Ronh
• Name: IKAROS family zinc finger 2; endonuclease-mediated mutation 1, Ronna Hertzano
• MGI ID: MGI:6269455
• Synonyms: Ikzf2^del890
• Gene: Ikzf2 Location: Chr1:69570373-69726404 bp, - strand Genetic Position: Chr1, 34.9 cM
• Alliance: Ikzf2^em1Ronh page

Mutation origin

• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exon 4 was targeted with four sgRNAs using CRISPR/Cas9 technology. The result is the deletion of exon 4, which contains the first zinc-finger domain. (J:267727)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ikzf2 Mutation: 44 strains or lines available

References

• Original: J:267727 Chessum L, et al., Helios is a key transcriptional regulator of outer hair cell maturation. Nature. 2018 Nov;563(7733):696-700
• All: 1 reference(s)