Adra2a^m1Btlr
Chemically induced Allele Detail

Summary

• Symbol: Adra2a^m1Btlr
• Name: adrenergic receptor, alpha 2a; mutation 1, Bruce Beutler
• MGI ID: MGI:6269429
• Synonyms: splenda
• Gene: Adra2a Location: Chr19:54033690-54037413 bp, + strand Genetic Position: Chr19, 49.04 cM
• Alliance: Adra2a^m1Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU-induced A to G transition at base pair 54,046,495 (v38) on chromosome 19, or base pair 1,314 in the GenBank genomic region NC_000085 encoding Adra2a. The mutation corresponds to residue 1,314 in the mRNA sequence NM_007417 within exon 1 of 1 total exons. The mutation results in an aspartic acid to glycine substitution at amino acid 94 (D94G) in the ADRA2A protein. (J:267700)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Adra2a Mutation: 23 strains or lines available

References

• Original: J:267700 Turer E, et al., Mutagenetix entry for splenda. MGI Direct Data Submission. 2018
• All: 1 reference(s)