Ptprc^M8Btlr
Chemically induced Allele Detail

Summary

• Symbol: Ptprc^M8Btlr
• Name: protein tyrosine phosphatase receptor type C; mutation 8, Bruce Beutler
• MGI ID: MGI:6268389
• Synonyms: Guotie3
• Gene: Ptprc Location: Chr1:137990599-138103446 bp, - strand Genetic Position: Chr1, 60.73 cM
• Alliance: Ptprc^M8Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU treatment induced a T-to-A transversion at base pair 138,078,451 (GRCm38) on chromosome 1, or base pair 97,306 in the GenBank genomic region NC_000067 encoding Ptprc. The mutation corresponds to residue 2,848 in the mRNA sequence NM_001111316 within exon 26 of 33 total exons. The mutation results in a tyrosine to asparagine substitution at position 937 (p.Y937N) in the CD45 protein. (J:267487)
• Inheritance: Semidominant

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ptprc Mutation: 212 strains or lines available

References

• Original: J:267487 Choi JH, et al., Mutagenetix entry for Guotie3. MGI Direct Data Submission. 2018
• All: 1 reference(s)