Crbn^em1Kish
Endonuclease-mediated Allele Detail

Summary

• Symbol: Crbn^em1Kish
• Name: cereblon; endonuclease-mediated mutation 1, Tadamitsu Kishimoto
• MGI ID: MGI:6267320
• Synonyms: CRBN^I391V
• Gene: Crbn Location: Chr6:106757162-106777038 bp, - strand Genetic Position: Chr6, 49.24 cM, cytoband E2
• Alliance: Crbn^em1Kish page

Mutation origin

• Strain of Origin: (C57BL/6 x DBA/2)F1

Mutation description

• Allele Type: Endonuclease-mediated (Humanized sequence)
• Mutation: Nucleotide substitutions
• Mutation details: CRISPR/Cas9 technology generated a single amino acid change at position 391, where isoleucine is replaced with valine (I391V). (J:267293)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Crbn Mutation: 32 strains or lines available

References

• Original: J:267293 Gemechu Y, et al., Humanized cereblon mice revealed two distinct therapeutic pathways of immunomodulatory drugs. Proc Natl Acad Sci U S A. 2018 Nov 13;115(46):11802-11807
• All: 1 reference(s)