Htra4^tm1.2Hohj
Targeted Allele Detail

Summary

• Symbol: Htra4^tm1.2Hohj
• Name: HtrA serine peptidase 4; targeted mutation 1.2, Josephine Hoh
• MGI ID: MGI:6266863
• Gene: Htra4 Location: Chr8:25514945-25528978 bp, - strand Genetic Position: Chr8, 13.7 cM
• Alliance: Htra4^tm1.2Hohj page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:266697
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 4. A FRT-flanked neomycin resistance cassette with a loxp site was inserted downstream of exon 5 and removed by flp-mediated recombination. A third loxP site was inserted downstream of exon 6. Cre-mediated recombination removed exons 4 through 6. (J:266697)

Expression

In Mice Carrying this Mutation:

15 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Htra4 Mutation: 35 strains or lines available

References

• Original: J:266697 Liu J, et al., Generation and characterization of mice with a conditional null allele of the HtrA4 gene. Mol Med Rep. 2015 Nov;12(5):6768-74
• All: 1 reference(s)