Brs3^tm2Rei
Targeted Allele Detail

Summary

• Symbol: Brs3^tm2Rei
• Name: bombesin-like receptor 3; targeted mutation 2, Marc L Reitman
• MGI ID: MGI:6259724
• Synonyms: Brs3^loxTB
• Gene: Brs3 Location: ChrX:56088434-56094118 bp, + strand Genetic Position: ChrX, 30.78 cM, cytoband A7.1-A7.2
• Alliance: Brs3^tm2Rei page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:253437
• Parent Cell Line: iTL IC1 (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: The targeting vector contains the 2924 bp loxTB (loxP-flanked transcriptional blocker) cassette inserted 421 bp into the first intron of the gene. The loxTB cassette contains a loxP-flanked neo cassette consisting of an SV40 enhancer, the neo gene, the HSV-TK pA sequence, and a transcriptional pause signal. (J:253437)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Brs3 Mutation: 15 strains or lines available

References

• Original: J:253437 Xiao C, et al., Bombesin-like receptor 3 (Brs3) expression in glutamatergic, but not GABAergic, neurons is required for regulation of energy metabolism. Mol Metab. 2017 Nov;6(11):1540-1550
• All: 2 reference(s)