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Tut4tm3.1Doca
Targeted Allele Detail
Summary
Symbol: Tut4tm3.1Doca
Name: terminal uridylyl transferase 4; targeted mutation 3.1, Donal O'Carroll
MGI ID: MGI:6259531
Synonyms: Tut4AAD
Gene: Tut4  Location: Chr4:108316623-108416618 bp, + strand  Genetic Position: Chr4, 50.55 cM
Alliance: Tut4tm3.1Doca page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:262343
Parent Cell Line:  A9 (ES Cell)
Strain of Origin:  (C57BL/6 x 129P2/OlaHsd)F1
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Nucleotide substitutions
 
Mutation detailsExon 15 was replaced with a modified one in which the codons for Asp1026 and Asp1028 were mutated to encode alanine. These mutations result in an enzymatically inactive protein. Flp-mediated recombination removed the selection cassette inserted downstream of the modified exon 15. (J:262343)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 1 RNA-Seq or microarray experiment(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tut4 Mutation:  80 strains or lines available
References
Original:  J:262343 Morgan M, et al., mRNA 3' uridylation and poly(A) tail length sculpt the mammalian maternal transcriptome. Nature. 2017 Aug 17;548(7667):347-351
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
06/12/2024
MGI 6.13
The Jackson Laboratory