Crb1^em7Boc
Endonuclease-mediated Allele Detail

Summary

• Symbol: Crb1^em7Boc
• Name: crumbs family member 1, photoreceptor morphogenesis associated; endonuclease-mediated mutation 7, Bo Chang
• MGI ID: MGI:6259440
• Gene: Crb1 Location: Chr1:139124794-139304838 bp, - strand Genetic Position: Chr1, 60.87 cM
• Alliance: Crb1^em7Boc page

Mutation origin

• Strain of Origin: B6.Cg-Crb1^rd8 Jak3^m1J/BocJ

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Intragenic deletion
• Mutation details: This TALEN-mediated mutation of nucleotide 3443-3487 was generated in the rd8 mutant allele and is a 45 bp deletion in exon 9 that restores the reading frame that was disrupted by the single base pair deletion of the rd8 mutation and causes a 15 amino acid in-frame deletion followed by a single amino acid substitution and causes a less severe phenotype than the rd8 mutation. (J:265859)
• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Crb1 Mutation: 92 strains or lines available

References

• Original: J:265859 Chang B, et al., Spontaneous Posterior Segment Vascular Disease Phenotype of a Mouse Model, rnv3, Is Dependent on the Crb1rd8 Allele. Invest Ophthalmol Vis Sci. 2018 Oct 1;59(12):5127-5139
• All: 1 reference(s)