Crb1^em6Boc
Endonuclease-mediated Allele Detail

Summary

• Symbol: Crb1^em6Boc
• Name: crumbs family member 1, photoreceptor morphogenesis associated; endonuclease-mediated mutation 6, Bo Chang
• MGI ID: MGI:6259439
• Gene: Crb1 Location: Chr1:139124794-139304838 bp, - strand Genetic Position: Chr1, 60.87 cM
• Alliance: Crb1^em6Boc page

Mutation origin

• Strain of Origin: B6.Cg-Crb1^rd8 Jak3^m1J/BocJ

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Intragenic deletion
• Mutation details: This TALEN-mediated mutation has a 285 bp deletion that includes 272 bp of exon 9 and 13 bp of intron 9, with cDNA sequencing showing the absence of 397 bp from the 3-prime end of exon 9 from the transcript. This is predicted to cause a 132 amino acid deletion then a frameshift resulting in 157 amino acid substitutions with 12 extra amino acids due to late termination. (J:265859)
• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Crb1 Mutation: 92 strains or lines available

References

• Original: J:265859 Chang B, et al., Spontaneous Posterior Segment Vascular Disease Phenotype of a Mouse Model, rnv3, Is Dependent on the Crb1rd8 Allele. Invest Ophthalmol Vis Sci. 2018 Oct 1;59(12):5127-5139
• All: 1 reference(s)