Crb1^em4Boc
Endonuclease-mediated Allele Detail

Summary

• Symbol: Crb1^em4Boc
• Name: crumbs family member 1, photoreceptor morphogenesis associated; endonuclease-mediated mutation 4, Bo Chang
• MGI ID: MGI:6259428
• Gene: Crb1 Location: Chr1:139124794-139304838 bp, - strand Genetic Position: Chr1, 60.87 cM
• Alliance: Crb1^em4Boc page

Mutation origin

• Strain of Origin: B6.Cg-Crb1^rd8 Jak3^m1J/BocJ

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This TALEN-induced mutation was generated in a strain with the retinal degeneration 8 (rd8) allele of this gene and has 5 noncontiguous base pairs deleted in exon 9, nucleotide 3481 from the original rd8 mutation and then nucleotides 3486-3489, which is predicted to cause a frameshift and result in the introduction of 11 novel amino acids before premature termination. (J:265859)
• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Crb1 Mutation: 92 strains or lines available

References

• Original: J:265859 Chang B, et al., Spontaneous Posterior Segment Vascular Disease Phenotype of a Mouse Model, rnv3, Is Dependent on the Crb1rd8 Allele. Invest Ophthalmol Vis Sci. 2018 Oct 1;59(12):5127-5139
• All: 1 reference(s)