Crb1^em3Boc
Endonuclease-mediated Allele Detail

Summary

• Symbol: Crb1^em3Boc
• Name: crumbs family member 1, photoreceptor morphogenesis associated; endonuclease-mediated mutation 3, Bo Chang
• MGI ID: MGI:6259427
• Gene: Crb1 Location: Chr1:139124794-139304838 bp, - strand Genetic Position: Chr1, 60.87 cM
• Alliance: Crb1^em3Boc page

Mutation origin

• Strain of Origin: B6.Cg-Crb1^rd8 Jak3^m1J/BocJ

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This TALEN-mediated 25 bp deletion in exon 9, from nucleotide 3467-3491, causes a frameshift and may cause a 44 amino acid substitution followed by early termination. This was generated in the retinal degeneration 8 allele, but encompasses the single point deletion of that mutation. (J:265859)
• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Crb1 Mutation: 92 strains or lines available

References

• Original: J:265859 Chang B, et al., Spontaneous Posterior Segment Vascular Disease Phenotype of a Mouse Model, rnv3, Is Dependent on the Crb1rd8 Allele. Invest Ophthalmol Vis Sci. 2018 Oct 1;59(12):5127-5139
• All: 1 reference(s)