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Endonuclease-mediated Allele Detail
Symbol: Sh3rf3em1(IMPC)J
Name: SH3 domain containing ring finger 3; endonuclease-mediated mutation 1, Jackson
MGI ID: MGI:6258587
Gene: Sh3rf3  Location: Chr10:58649181-58974738 bp, + strand  Genetic Position: Chr10, 29.41 cM
Alliance: Sh3rf3em1(IMPC)J page
IMPC: Sh3rf3 gene page
Strain of Origin:  C57BL/6NJ
Project Collection: IMPC
Allele Type:    Endonuclease-mediated (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsThis allele was generated at The Jackson Laboratory by electroporating Cas9 protein and 2 guide sequences GTACCATCCCAAGGTCAACA and GAGAATGTCGACAGACATGA, which resulted in a 361 bp deletion beginning at Chromosome 10 position 59,071,696 bp and ending after 59,072,056 bp (GRCm38/mm10). This mutation deletes ENSMUSE00001288805 (exon 5) and 256 bp of flanking intronic sequence including the splice acceptor and donor and is predicted to cause a change of amino acid sequence after residue 428 and early truncation 12 amino acids later. (J:188991)
Inheritance:    Not Specified
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Sh3rf3 Mutation:  51 strains or lines available
Original:  J:188991 The Jackson Laboratory, Alleles produced for the KOMP project by The Jackson Laboratory. MGI Direct Data Submission. 2012;
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.13
The Jackson Laboratory