Ksr2^tm1Rlw
Targeted Allele Detail

Summary

• Symbol: Ksr2^tm1Rlw
• Name: kinase suppressor of ras 2; targeted mutation 1, Robert E Lewis
• MGI ID: MGI:6258545
• Gene: Ksr2 Location: Chr5:117552067-117906061 bp, + strand Genetic Position: Chr5, 56.88 cM
• Alliance: Ksr2^tm1Rlw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:155434
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: DBA/1LacJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassettte replaced most of exon 4 along with the splice junction between exon 4 and intron 4. (J:155434)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ksr2 Mutation: 43 strains or lines available

References

• Original: J:155434 Costanzo-Garvey DL, et al., KSR2 is an essential regulator of AMP kinase, energy expenditure, and insulin sensitivity. Cell Metab. 2009 Nov;10(5):366-78
• All: 3 reference(s)