Uqcrfs1^tm1.1Ptsc
Targeted Allele Detail

Summary

• Symbol: Uqcrfs1^tm1.1Ptsc
• Name: ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1; targeted mutation 1.1, Paul T Schumacker
• MGI ID: MGI:6258349
• Synonyms: RISP^flox
• Gene: Uqcrfs1 Location: Chr13:30724295-30729299 bp, - strand Genetic Position: Chr13, 13.23 cM, cytoband A3.3
• Alliance: Uqcrfs1^tm1.1Ptsc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:266893
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exon 2 was flanked by loxP sites. A PGK-neomycin selection cassette flanked by FRT sites was removed via Flp-mediated recombination. (J:266893)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Uqcrfs1 Mutation: 19 strains or lines available

References

• Original: J:266893 Waypa GB, et al., Superoxide generated at mitochondrial complex III triggers acute responses to hypoxia in the pulmonary circulation. Am J Respir Crit Care Med. 2013 Feb 15;187(4):424-32
• All: 10 reference(s)