Abca7^{tm1.1(ABCA7)Pahnk}
Targeted Allele Detail

Summary

• Symbol: Abca7^{tm1.1(ABCA7)Pahnk}
• Name: ATP-binding cassette, sub-family A member 7; targeted mutation 1.1, Jens Pahnke
• MGI ID: MGI:6258226
• Synonyms: hABCA7^flx
• Gene: Abca7 Location: Chr10:79832328-79851406 bp, + strand Genetic Position: Chr10, 39.72 cM
• Alliance: Abca7^{tm1.1(ABCA7)Pahnk} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:284731
• Parent Cell Line: C2J (ES Cell)
• Strain of Origin: B6(Cg)-Tyr^c-2J/J

Mutation description

• Allele Type: Targeted (Conditional ready, Inserted expressed sequence, Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The human sequence flanked by loxP replaced the endogenous sequence. Flp-mediated recombination removed the selection cassette. (J:284731)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Abca7 Mutation: 88 strains or lines available

References

• Original: J:284731 Krohn M, et al., Generation and Characterization of an Abcc1 Humanized Mouse Model (hABCC1(flx/flx) ) with Knockout Capability. Mol Pharmacol. 2019 Aug;96(2):138-147
• All: 2 reference(s)