Gpx4^tm1.1Adbo
Targeted Allele Detail

Summary

• Symbol: Gpx4^tm1.1Adbo
• Name: glutathione peroxidase 4; targeted mutation 1.1, Astrid Borchert
• MGI ID: MGI:6257859
• Synonyms: Sec46Ala-Gpx4^-
• Gene: Gpx4 Location: Chr10:79883000-79892273 bp, + strand Genetic Position: Chr10, 39.72 cM
• Alliance: Gpx4^tm1.1Adbo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:264805
• Parent Cell Line: iTL BA1 (ES Cell)
• Strain of Origin: (C57BL/6NTac x 129S6/SvEvTac)F1

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Exon 2 was replaced with a modified one in which the selenocysteine (TGA) was mutated to an alanine encoding triplet (GCA) at position 46 (Sec46Ala). Flp-mediated recombination removed the FRT- and loxP-flanked neomycin resistance cassette inserted downstream of exon 4. (J:264805)

Expression

In Mice Carrying this Mutation:

36 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gpx4 Mutation: 80 strains or lines available

References

• Original: J:264805 Brutsch SH, et al., Expression of inactive glutathione peroxidase 4 leads to embryonic lethality, and inactivation of the Alox15 gene does not rescue such knock-in mice. Antioxid Redox Signal. 2015 Feb 1;22(4):281-93
• All: 3 reference(s)