Pthlh^em1Nono
Endonuclease-mediated Allele Detail

Summary

• Symbol: Pthlh^em1Nono
• Name: parathyroid hormone-like peptide; endonuclease-mediated mutation 1, Noriaki Ono
• MGI ID: MGI:6257030
• Synonyms: Pthrp-mCherry, Pthrp^mCHerry
• Gene: Pthlh Location: Chr6:147153607-147165511 bp, - strand Genetic Position: Chr6, 78.19 cM, cytoband F-G
• Alliance: Pthlh^em1Nono page

Mutation origin

• Strain of Origin: (C57BL/6 x SJL)F2

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: CRISPR/Cas9 genome editing is used to replace the start codon in exon 2 of the gene with a Kozak-mCherry-bGHpA cassette. (J:266751)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pthlh Mutation: 19 strains or lines available

References

• Original: J:266751 Mizuhashi K, et al., Resting zone of the growth plate houses a unique class of skeletal stem cells. Nature. 2018 Nov;563(7730):254-258
• All: 4 reference(s)