Flna^tm1.1Mfj
Targeted Allele Detail

Summary

• Symbol: Flna^tm1.1Mfj
• Name: filamin, alpha; targeted mutation 1.1, Michael F Jantsch
• MGI ID: MGI:6256976
• Synonyms: FLNA^deltaECS
• Gene: Flna Location: ChrX:73267067-73293426 bp, - strand Genetic Position: ChrX, 37.89 cM
• Alliance: Flna^tm1.1Mfj page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:266328
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A floxed neomycin resistance cassette replaced a 228 bp region between in intron 42-43 harboring the editing complementary site (ECS). Cre-mediated recombination removed the selection cassette. (J:266328)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Flna Mutation: 20 strains or lines available

References

• Original: J:266328 Jain M, et al., RNA editing of Filamin A pre-mRNA regulates vascular contraction and diastolic blood pressure. EMBO J. 2018 Oct 1;37(19)
• All: 1 reference(s)