Ucp1^em1Yshu
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ucp1^em1Yshu
• Name: uncoupling protein 1 (mitochondrial, proton carrier); endonuclease-mediated mutation 1, Yi-Shuian Huang
• MGI ID: MGI:6251547
• Synonyms: Ucp1deltaL line 30
• Gene: Ucp1 Location: Chr8:84016981-84025081 bp, + strand Genetic Position: Chr8, 39.65 cM
• Alliance: Ucp1^em1Yshu page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Modified isoform(s))
• Mutation: Intragenic deletion
• Mutation details: CRISPR-targeting deedted a 377 bp region in the 3' UTR within exon 6 containing two Hex (AAUAAA) and 2 cytoplasmic polyadenylation elements (CPE) regions. This region is found within the long form transcripts. Lines 30 (Ucp1^em1Yshu) and 64 (Ucp1^em2Yshu) were generated. (J:266624)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ucp1 Mutation: 51 strains or lines available

References

• Original: J:266624 Chen HF, et al., CPEB2-dependent translation of long 3'-UTR Ucp1 mRNA promotes thermogenesis in brown adipose tissue. EMBO J. 2018 Oct 15;37(20)
• All: 1 reference(s)