Casp8^em1Vnce
Endonuclease-mediated Allele Detail

Summary

• Symbol: Casp8^em1Vnce
• Name: caspase 8; endonuclease-mediated mutation 1, Russell E Vance
• MGI ID: MGI:6246546
• Gene: Casp8 Location: Chr1:58834553-58886663 bp, + strand Genetic Position: Chr1, 29.19 cM, cytoband B
• Alliance: Casp8^em1Vnce page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 genome editing is used to generate a 2 bp deletion in exon 3 of the gene, creating a null allele. (J:255168)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Casp8 Mutation: 45 strains or lines available

Notes

Cas9 and guide RNAs were co-injected into embryos derived from Ripk3^tm1Xidw and Casp1^tm1Sesh mice on a C57BL/6, 129S2/SvPas, 129X1/SvJ and 129S1/Sv mixed genetic background.

References

• Original: J:255168 Rauch I, et al., NAIP-NLRC4 Inflammasomes Coordinate Intestinal Epithelial Cell Expulsion with Eicosanoid and IL-18 Release via Activation of Caspase-1 and -8. Immunity. 2017 Apr 18;46(4):649-659
• All: 3 reference(s)