Gt(ROSA)26Sor^{tm1(Casp1)Vnce}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1(Casp1)Vnce}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Russell Vance
• MGI ID: MGI:6246543
• Synonyms: iCasp1
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1(Casp1)Vnce} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:255168
• Parent Cell Line: JM8.F6 (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm1(Casp1)Vnce} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Casp1 (MGI:96544)

• Mutation details: The targeting vector includes a loxP-flanked transcriptional Stop cassette (in reverse transcriptional orientation) followed by mouse Casp1 cDNA and IRES-EGFP is introduced into the Gt(ROSA)26Sor gene via homologous recombination. (J:255168)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 944 strains or lines available

References

• Original: J:255168 Rauch I, et al., NAIP-NLRC4 Inflammasomes Coordinate Intestinal Epithelial Cell Expulsion with Eicosanoid and IL-18 Release via Activation of Caspase-1 and -8. Immunity. 2017 Apr 18;46(4):649-659
• All: 2 reference(s)