Casp1^em1Vnce
Endonuclease-mediated Allele Detail

Summary

• Symbol: Casp1^em1Vnce
• Name: caspase 1; endonuclease-mediated mutation 1, Russell E Vance
• MGI ID: MGI:6246541
• Gene: Casp1 Location: Chr9:5298517-5307281 bp, + strand Genetic Position: Chr9, 2.46 cM
• Alliance: Casp1^em1Vnce page

Mutation origin

• Strain of Origin: B6(Cg)-Tyr^c-2J/J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 genome editing is used to generate a 10 bp deletion (AGGGGCTCAC) in exon 8 of the gene, creating a null allele. (J:255168)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Casp1 Mutation: 43 strains or lines available

References

• Original: J:255168 Rauch I, et al., NAIP-NLRC4 Inflammasomes Coordinate Intestinal Epithelial Cell Expulsion with Eicosanoid and IL-18 Release via Activation of Caspase-1 and -8. Immunity. 2017 Apr 18;46(4):649-659
• All: 26 reference(s)