Gsdmd^em1Vnce
Endonuclease-mediated Allele Detail

Summary

• Symbol: Gsdmd^em1Vnce
• Name: gasdermin D; endonuclease-mediated mutation 1, Russell E Vance
• MGI ID: MGI:6246539
• Synonyms: Gsdmd^-
• Gene: Gsdmd Location: Chr15:75734176-75739257 bp, + strand Genetic Position: Chr15, 35.0 cM, cytoband D3-E1
• Alliance: Gsdmd^em1Vnce page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Insertion
• Mutation details: CRISPR/Cas9 genome editing was used to generate a 19 bp and a 1 bp (20 bp total) insertion in exon 2 that creates a knock-out allele (ATGTTGTCAGG became ATGcTTGaaggtgtgtggatgcagagTCAGG). (J:255168)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gsdmd Mutation: 33 strains or lines available

References

• Original: J:255168 Rauch I, et al., NAIP-NLRC4 Inflammasomes Coordinate Intestinal Epithelial Cell Expulsion with Eicosanoid and IL-18 Release via Activation of Caspase-1 and -8. Immunity. 2017 Apr 18;46(4):649-659
• All: 29 reference(s)