Nup205^em1(IMPC)J
Endonuclease-mediated Allele Detail

Summary

• Symbol: Nup205^em1(IMPC)J
• Name: nucleoporin 205; endonuclease-mediated mutation 1, Jackson
• MGI ID: MGI:6209645
• Gene: Nup205 Location: Chr6:35154551-35224534 bp, + strand Genetic Position: Chr6, 15.24 cM, cytoband B1
• Alliance: Nup205^em1(IMPC)J page
• IMPC: Nup205 gene page

Mutation origin

• Strain of Origin: C57BL/6NJ
• Project Collection: IMPC

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele was generated at The Jackson Laboratory by Microinjection Cas9 mRNA and 2 guide sequences AGGGGATATGAGGCAACACG and TGAAGCTAGAACCCCTATCT, which resulted in a 605 bp deletion beginning at Chromosome 6 position 35,186,016 bp and ending after 35,186,665 bp (GRCm38/mm10). This mutation deletes ENSMUSE00000469332 (exon 3) and 478 bp of flanking intronic sequence including the splice acceptor and donor and is predicted to cause a change of amino acid sequence after residue 57 and early truncation 15 amino acids later. (J:188991)
• Inheritance: Not Specified

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Nup205 Mutation: 103 strains or lines available

References

• Original: J:188991 The Jackson Laboratory, Alleles produced for the KOMP project by The Jackson Laboratory. MGI Direct Data Submission. 2012
• All: 2 reference(s)