Trem2^em1Bwef
Endonuclease-mediated Allele Detail

Summary

• Symbol: Trem2^em1Bwef
• Name: triggering receptor expressed on myeloid cells 2; endonuclease-mediated mutation 1, Benedikt Wefers
• MGI ID: MGI:6209376
• Synonyms: T66M
• Gene: Trem2 Location: Chr17:48653429-48659304 bp, + strand Genetic Position: Chr17, 23.99 cM, cytoband C
• Alliance: Trem2^em1Bwef page

Mutation origin

• Strain of Origin: (C57B/6J x DBA/2J)F1 x FVB/N

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Nucleotide substitutions
• Mutation details: The allele was generated by injecting cas9 nuclease and a single guide RNA designed to introduce an threonine to methionine (T66M) point mutation by a CA to TG substitution and two additional silent mutations for genotyping purposes. (J:242126)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trem2 Mutation: 65 strains or lines available

References

• Original: J:242126 Kleinberger G, et al., The FTD-like syndrome causing TREM2 T66M mutation impairs microglia function, brain perfusion, and glucose metabolism. EMBO J. 2017 Jul 03;36(13):1837-1853
• All: 2 reference(s)